[ForkMeOnTinder]

This is just begging the question: surely you don't watch videos while driving? And if you just want the audio, there are music-focused YT apps (ViMusic, or like sibling said, YMusic)

[explorigin]

Newpipe has a built-in "Play in Background" feature that would be awesome while driving. There are tons of podcast-like content videos on YT that would be fine for a commute.

[jcalve]

It works in my car, I have it running in background mode and I just select the media player in the car menu, no Android auto needed.