My wife has a similar problem with the iMac supplied wireless mouse. She'll go to click-drag something and catch the power switch, which is on the underside of the mouse, on the mousepad turning off the mouse. This has happened maybe four times in the two years we've had it, but everytime it's been "The computer crashed!" and gets power-cycled, losing work. Of course it's still "crashed" when it comes back up because the mouse is turned off. This post makes me feel like I should put a sticky note on there to check the mouse next time.
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