[picometer]

Wow - can you elaborate on your process to “debug” these different layers? What comprises your personal or team’s feedback loop, given that 6 months is short? (I suspect it’s a lot of sequencing?) Are there good comparisons to be made with getting acquainted with a new codebase/technical system? Are there any particular computational tools involved? Pardon all the questions, this stuff is fascinating!

[r0ze-at-hn]

To be clear this is/was a hobby project. Getting access to DNA files is required yes, but sequencing wasn't really the limiting factor. It started with simply poking around my DNA file and then some friends many of which were only done on 23andme. Most of the time was spent reading countless papers and making hypothesis, trying to invalidate them and iterating. Constantly seeking out new ways to look at the problem and going from there. Every time I got a new DNA file from someone I could see how their dna fit into the current hypothesis. Because every DNA was different it was a great way to test them. It anything it made my job easier. I wasn't looking for a single snp, but common patterns.

Sometimes this has involved using nebula and their whole genome sequencing dna test to get much more accurate data, but more often than not the cheap dna tests most people do were good enough.

As for actual programs, I did write some quick and dirty scripts to scan dna files for specific snps, but mostly I would just read them as the parts I needed were not that long.

There is a fair amount of phenotype data to start with. What ultimately started this was knowing 1) that there was a number of conditions that are seen in statistically weird numbers in the LGBT and 2) sex hormone levels in the LGBT are not exactly what you would expect.

My goto fun question when talking with someone in the LGBT is if they have hypermobility. A good percentage do. In one specific example those with classical like EDS will have 21-OHD and thus POTS and elevated 17-OHP, backdoor DHT production (aka PCOS for women) etc.

The real question I have been pondering is what exactly do I do with this as this is just a fun puzzle, not my job, I don't work for any school etc.

[calf]

I don't get it. If you can solve for LGBT genes that easily, then why isn't this in the news? Surely academic scientists would have tried this if all you needed was some scripting to find patterns?

[justinclift]

> what exactly do I do with this

Whatever you do, maybe do it anonymously?

It really sounds like it could badly trigger many people who will viciously attack others, actively attempt to destroy their lives, etc.

Be careful? :)

[satokema]

if nothing else post about it.

everyone loves a good story.