[amethyst]

Imagine being on STS-1, piloting a shuttle that had literally never been to space before in any form.

https://en.wikipedia.org/wiki/STS-1

[seer]

Well at least they would have no one else to blame but themselves. As far as I remember it was the pilots that insisted on the shuttle to be not be 100% automated, so they had to do it this way. The soviets just made the whole shuttle automated so it could be tested without risk to crew.

[dotnet00]

Or similarly with Orion, which has never been to space with a fully functioning life support system, and will not be until it carries a crew.