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lbeltrame | 1 year ago

Actual ovarian cancer researcher here. To be perfectly honest, it is the first time I've heard of talc or asbestos being linked to ovarian cancer.

Mesothelioma is one thing. One of the drivers of malignant mesothelioma (which is caused by inhalation of asbestos) is a chronic state of inflammation caused by the inability to remove or degrade the asbestos fibers.

But in ovarian cancer the major mechanisms are not inflammatory in nature. Depending on the type (there are a few), usually it's a mutation in a key gene that then causes other, larger alterations in the chromosomes and ultimately a malignant outcome.

Now, mutations can be caused by inflammation (in particular due to the release of reactive oxygen species or ROS), but as fa as I'm aware, mechanisms of asbestos-like chronic inflammation being a cause (not a link, a cause, I mean with a molecular explanation) are not widely reported in literature and I haven't heard anything like that from my peers (much more knowledgeable than me on the topic).

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