[coriny]

There is a biannual structural prediction contest called CASP [1], in which a set of newly determined structures is used to benchmark the prediction methods. Some of these structures will be "novel", and so can be used to estimate the performance of current methods on predicting "structure that we have no baseline to start with".

CASP-style assessments are something that should done for more research fields, but it's really hard to persuade funders and researchers to put up the money and embargo the data as required.

[1] https://en.wikipedia.org/wiki/CASP