[Arthanos]

50mg 3x a day, according to the study: https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.124.32432...

Seems high to me, but I've never taken the drug. I assume most people take it just a few times a week for it's intended use? Is anyone aware of research that shows positive benefits to health at recreational doses?

[Aurornis]

That’s a standard dose. 3X per day is because it has a short half life.

> Is anyone aware of research that shows positive benefits to health at recreational doses?

Recreational doses? What does that mean? Excessive vasodilation isn’t going to be fun. You actually need some vasoconstriction to balance your blood pressure. Too much and you’re just going to get headaches and lightheaded. Excessive vasodilation would be expected to worsen cognition.

[AbstractH24]

So Extended Release Sindafil is about to hit the market hard?

Reminds of me how ER Guanfacine was brought to market as and ADHD drugs.

Why invent new drugs when you can put new wrappers on old ones?

[ezekiel68]

> Recreational doses? What does that mean?

I mean, we don't need to act obtuse here in the name of pedantry. Commenter was clearly referring to occasional use for on-label indication.