[isotropy]

I read this as basically arguing that our filters throw up too many false negatives, like Kariko, in a high-risk/high-reward environment. It’s saying the cost of false negatives is way higher than the system realizes, and that’s because the system has drifted to be too much like the collaborative, incremental workplace that most of us live in. Typical work teams pay a high cost for false positives when hiring, so they guard against them at the cost of way more false negatives. The doesn’t work as well for moonshot fields.