Energy depletion indicated by the reduced levels of ATP and GTP has been described in several studies on infectious diseases and endotoxemia16,17,18. Reduced ATP levels in blood and various organs, including the liver, have been previously associated with influenza virus infection in a mouse model16. Decreased GTP levels have been shown in the lung tissues of rabbits treated with bacterial endotoxin lipopolysaccharide17. Increases in the serum levels of hypoxanthine and inosine have also been reported in patients with primary dengue virus infection at the febrile stage, suggesting an imbalance of ATP and/or GTP synthesis and degradation during the acute stage of the dengue fever18. These studies and ours indicate that regulatory energy depletion is a common symptom of infectious diseases.
In this article, we provide a novel hypothesis to describe how an increase in cellular adenosine triphosphate (c-ATP) can potentially improve the efficiency of innate and adaptive immune systems to either prevent or fight off COVID-19.
Spod_Gaju|1 year ago
https://www.nature.com/articles/s41598-020-67879-6
Energy depletion indicated by the reduced levels of ATP and GTP has been described in several studies on infectious diseases and endotoxemia16,17,18. Reduced ATP levels in blood and various organs, including the liver, have been previously associated with influenza virus infection in a mouse model16. Decreased GTP levels have been shown in the lung tissues of rabbits treated with bacterial endotoxin lipopolysaccharide17. Increases in the serum levels of hypoxanthine and inosine have also been reported in patients with primary dengue virus infection at the febrile stage, suggesting an imbalance of ATP and/or GTP synthesis and degradation during the acute stage of the dengue fever18. These studies and ours indicate that regulatory energy depletion is a common symptom of infectious diseases.
Spod_Gaju|1 year ago
The powerful immune system against powerful COVID-19: A hypothesis
https://www.sciencedirect.com/science/article/pii/S030698772...
In this article, we provide a novel hypothesis to describe how an increase in cellular adenosine triphosphate (c-ATP) can potentially improve the efficiency of innate and adaptive immune systems to either prevent or fight off COVID-19.
Spod_Gaju|1 year ago
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