Deletion of Il11 extended the lives of mice by 25%

[Supermancho]

I immediately wonder how this affected the EOL conditions of those mice.

[rexreed]

They outlived their retirement savings and had to re-enter the workforce. It's just a rat race, isn't it.

[beowulfey]

Article states they had fewer biomarkers of aging, and showed less age-associated obesity, fraility, and metabolic decline. So their "youth" period extended longer.

Actually the point of healthspan vs lifespan is made in the introduction -- it was a justification for using mice for this study, which have clear health phenotypes that are analogous to humans.

[gumby]

It switched them from CRLF to \n?

[xk_id]

The only significant, deleterious phenotype in il-11 KO mice is the inability to sustain pregnancy. So far it seems to have a very high safety profile.

[ChrisArchitect]

[dupe]

Discussion: https://news.ycombinator.com/item?id=40987224