[jayyhu]

Edit: See comment below; The RP2350 can be powered by a 5V supply.

[Findecanor]

To clarify: You can connect a 5V power source by connecting it to the VSYS pin which leads into the on-board voltage regulator.

But the µC itself runs on 3.3V and is not totally 5V-capable. You'd need level converters to interface with 5V.

[snvzz]

>You'd need level converters to interface with 5V.

Part of the GPIOs are CMOS are 5v-tolerant, and TTL considers 2v HIGH, thus it is possible to interface some 5v hardware directly.

[jayyhu]

You're right, after re-reading the Power section on the datasheet it seems connecting 5V to the VREG_VIN should suffice to power the digital domains, but if you want to use the ADC, you still need a external 3.3V source.

[giantg2]

I'd rather have it run on the lower voltage - generally easier to step down than buck up. Either way, the modules are pretty cheap, small, and easy to find.

[skykooler]

How much tolerance does that have - can it run directly off a 3.7v lithium ion battery?

[jayyhu]

Yep, they explicitly call out that the onboard voltage regulator can work with a single lithium ion cell.