[CrimpCity]

Short answer no. This is because what gets exhausted is aerobic capacity. When you get within striking range The Rock will still have access to fast twitch muscles & some reduced amount of glycogen for energy release. This would probably be enough to grab you and choke you out. Basically the Mountain vs the Viper fight from game of thrones.

If you were of similar size then yes. Basically being smaller really sucks in a fight. So if you can reasonably deflect the Rocks wrestling & grappling offensive you could rope a dope him causing him to gas out and then win. Higher weight MMA fighters & boxers use this tactic all the time. They let their opponent “punch themselves out” and then get off their own offense.

[fumar]

Wouldn’t the endurance preferred human eventually reach a safe distance and not have to fight?

[gherkinnn]

Also known as "running away", the first line of self defence.

[CrimpCity]

Nope. OP stipulated that at some point mortal combat happens and also suggests that it happens within arms length for example dropping a large rock on an even larger Rock.