[owenmarshall]

One important note with mpox is that there are two distinct lineages of the virus at play: the outbreak in the US in 2022 was clade IIb, which seems to be difficult to spread - hence the “close physical contact” attribution. It also had a low observed CFR.

Clade I mpox is the current outbreak under discussion. It spreads far easier - most pathways are likely not sexual contact - and has an observed CFR 10x higher than IIb.

In other words: this is a very different virus than what we saw in 2022.

https://centerforhealthsecurity.org/sites/default/files/2024...