[semaglp1]

There's some evidence of bone density being affected negatively, which could be prevented with exercise: https://jamanetwork.com/journals/jamanetworkopen/fullarticle...

I've also read anecdotal reports of skin burning sensations from people that take it.

If people can take it to lose weight and curb food addiction while also beginning strength training for long term health, I think that's a positive.

[djur]

In any case, long-term obesity leads to (and is worsened by) decreased exercise, which results in decreased bone density and muscle loss. There might be an argument for avoiding GLP-1 agonists for slightly overweight people, but for obese people it seems unlikely that the risks outweigh the benefits.

[semaglp1]

Agreed! I'm not against people taking them if it helps.