[notduncansmith]

This is wrong. You can absolutely dose psylocybin at levels that make a meaningful difference in experience (certainly enough to have an anti-depressant effect) without “tripping” or being in any way impaired. For many adults, this will be around 100-200mg of psilocybin.

[llamaimperative]

It's not a question of impairment, it's a question of whether you come to some determination of whether you are in the control group or not.

[dymk]

Microgram, not milligram, of psilocybin. 100mg of psilocybin would be about 50-200 grams of dried cubensis mushroom.

There have been studies on microdosing, but it’s also valuable to know what happens at perceptible doses as well. It’s certainly a different experience.