[davebrown10]

    (1996) "Excessive signaling of arachidonic acid (AA) metabolites has been associated with various chronic degenerative or autoimmune diseases, and intervention with the metabolism of AA is widely employed therapeutically in these afflictions. In essence, AA is the most biologically active unsaturated fatty acid in higher animals. Its concentration in membranes and its magnitude of effects depend on its amount, or that of its precursors and analogues, in the diet. The tendency of the field of nutrition to ignore the role of dietary AA will optimistically be reversed in the future." The article also said, "The underlying rationale for this symposium is that dietary AA is perhaps the single most important nutritional determinant in regulating AA levels in Americans. This may ultimately account in part for the striking differences in chronic diseases between strict vegetarians and the bulk of the omnivorous population." https://pubmed.ncbi.nlm.nih.gov/8642436/

Both animals and humans have endocannabinoid systems that operate identically in terms of physiological outcomes. Consequently, excessive arachidonic acid in cell membranes has pathologically consequences. https://johnditragliamd.substack.com/p/the-other-fat-science

[KempyKolibri]

As I said, happy to move onto AA once we’ve closed off the n3:n6 ratio thing. So do you have any evidence that the ratio is an issue in humans, or do you concede there’s no such evidence currently?