[falcolas]

The only time people didn't have a choice is when they wanted to interact with society. Something which, thanks to the internet and delivery services, is almost wholly optional in this day and age.

But, the moment you start interacting with society at large, you have to follow that society's laws. Laws which have always included things like quarantining and mandatory vaccinations to prevent the spread of infectious disease.

See, as one example, the 1920 response to the Spanish Flu epidemic.