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Fizzino's HPF study, while not an RCT, is the most comprehensive study to date done on HPFs. She's also identified links between HPF proliferation and tobacco companies: https://onlinelibrary.wiley.com/doi/10.1111/add.16332

I cited RCTs in other comments pertaining to macronutrient intake and metabolic health. Lustig instead relies on mouse models and mechanistic speculation to make his case, because the RCTs in humans haven't shown sugar to cause all the ills he claims, without associated weight gain. Meanwhile saturated fat (given the available literature) ironically seems to be able to do much of what Lustig claims (impair insulin sensitivity, increase visceral fat), even without weight gain.