[JZL003]

You can use rclone mount, depends on how much you're flipping through files or actually doing lots of IO

I wouldn't want to host fastqs or something and use this for alignment, but for spot checking raw fastqs it could be nice

[therealmarv]

This reminds me on using rclone mount on Terrabytes of data and I mostly wanted some "smaller" files between 200kb-1.5MB in a single directory. I made rclone mount significantly faster when rclone mount caches into a Ramdisk (there is a free tool to make Ramdisks on macOS too).