> We identify NAS-altered microbial metabolic pathways that are linked to host susceptibility to metabolic disease, and demonstrate similar NAS-induced dysbiosis and glucose intolerance in healthy human subjects. Collectively, our results link NAS consumption, dysbiosis and metabolic abnormalities, thereby calling for a reassessment of massive NAS usage
I note that "normal" here should be read as "common during the last 50years (or less)", where the last 50ears is quite reductive in human dietary habits.
This paper you linked does not even involve aspartame. The only sweetener they experimented with is saccharin. You can check out the main figures from the link below:
I would be very reluctant to read too deep into this given saccharin is known to behave very differently in animal models - for a long time it was thought to cause bladder cancer, but follow up studies proved that it’s an idiosyncratic reaction only found in female lab rats and no other gender/species combination. Not to mention the dose used was unrealistic to begin with.
It’s entirely plausible that sugar analogs like sucralose and non-calorific sugar alcohols such as erythritol and maltitol can cause long term changes in the gut biome but high quality evidence is still lacking.
aziaziazi|1 year ago
> We identify NAS-altered microbial metabolic pathways that are linked to host susceptibility to metabolic disease, and demonstrate similar NAS-induced dysbiosis and glucose intolerance in healthy human subjects. Collectively, our results link NAS consumption, dysbiosis and metabolic abnormalities, thereby calling for a reassessment of massive NAS usage
I’d be glad to see the full paper
https://pubmed.ncbi.nlm.nih.gov/25231862/
> normal soda consumption levels in humans
I note that "normal" here should be read as "common during the last 50years (or less)", where the last 50ears is quite reductive in human dietary habits.
Laforet|1 year ago
https://www.researchgate.net/publication/265791239_Artificia...
I would be very reluctant to read too deep into this given saccharin is known to behave very differently in animal models - for a long time it was thought to cause bladder cancer, but follow up studies proved that it’s an idiosyncratic reaction only found in female lab rats and no other gender/species combination. Not to mention the dose used was unrealistic to begin with.
It’s entirely plausible that sugar analogs like sucralose and non-calorific sugar alcohols such as erythritol and maltitol can cause long term changes in the gut biome but high quality evidence is still lacking.
nprateem|1 year ago
Research suggests a link to cancer. It'd be bad for your microbiome if you die.