These organizations consist of political appointees and civil servants. It is customary to replace all of the political appointees. Civil servants however have a lot of job protections and can only be fired for a limited set of reasons. Typically, a new administration would appoint new political appointees to the various departments (many of whom need to be confirmed by the Senate) and those appointees would then exert their influence on the department by shifting priorities around and they could even alter the hiring process to target more "aligned" individuals for the open civil servant roles. But they cannot just do a wholesale house cleaning. The high level purpose and the budget/size of the organization is determined by Congress and the political appointees are constrained by that.So this is in fact very different from how things normally work.
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