[prododev]

I mean, it is kinda quacky to treat someone with that until it's demonstrated by science. I'm open to the idea that light is an important regulator, but that effect should be easily observable if it's truly effective.

[cowsaymoo]

I'm no expert but my gist is that light interacts with an enzyme in the electron transport chain (cytochrome c oxidase). CCO is embedded in the inner membrane of mitochondria, and nitric oxide binds to CCO which temporarily inhibits cellular respiration as a natural metabolic regulation to control oxidative stress. Red and NIR light can photodissociate NO from CCO with the right intensity and wavelength, which restarts cellular respiration and ATP production. The release of NO into the bloodstream can secondarily trigger other chemical pathways involved in vasodilation and reactive oxygen species management.

Edit: found a wiki with more details:

https://en.wikipedia.org/wiki/Light-emitting_diode_therapy#P...

[BobaFloutist]

In general, with a very few exceptions, if the body has a regulatory mechanism there's at least some reason for it, and tinkering with it without understanding it can have unpredictable downsides.

>as a natural metabolic regulation to control oxidative stress

That sounds like something I'd be very wary of manipulating without a good deal of clinical trials. Isn't oxidative stress one of like three primary hypothesized mechanisms of aging?

[Etheryte]

The topmost comment in this comment thread starts with the fact that there are over a thousand studies on this already, no? Even if the whole effect isn't well understood, it seems like there is some science behind this.

[0xEF]

One could argue that the research goes all the way back to Dr Frederick Cook aboard the Belgica during an Antarctic expedition I which they became trapped by the sea ice. The men suffered from multiple maladies, scurvy included, with one of the prescribed treatments being to stand nude near a blazing fire for an hour. If his notes are to be believed, the men saw some immediate changed in their overall health beyond simply getting warm. By some accounts, he became a bit of a fanatic about how much we humans need the sun, after that.

[Angostura]

There maybe a thousand studies.

How many well-designed double-blind studies in humans? That’s the question

[ankitml]

i dont know what you mean by science. There are literally 1000s of research papers showing mitochondrial "horsepower" with red light on every type of tissue. Cells heal themselves as first thing when they get extra energy. Do you want your neighborhood clinic to validate before trying some light samples out?