[hotstickyballs]

It's destructive if you can't reach your remote devices anymore. See also jeff geerling's "It was DNS T-Shirt" https://www.redshirtjeff.com/shop/p/it-was-dns-shirt

[OJFord]

Only if they're configured to explode if not pinged for 30s or something.

[master_crab]

The only times I have seen this happen is when the remote devices were communicating with something on blacklist (which should be concerning anyway, but also a quick fix if not) or doing something naughty like not using the DNS server broadcast by DHCP.