You're right, of course. There is a difference between methylphenidate and other amphetamine-class stimulants for ADHD, but I didn't know what to call it.
I should have said it's not a direct agonist. Instead of directly causing dopamine release, it acts as an allosteric modulator on DAT to affect reuptake.
I had a study in mind that found switching to MPH was effective at lowering the equivalent dose (the tolerance did not carry over), but my Googling is failing me right now. Appreciate the correction.
Thank you for the clarification. I didn’t know about the differing mechanism, and you’ve sent me off on a research rabbit hole. Always a happy result of an HN thread. I appreciate your follow up!
loves_mangoes|1 year ago
I should have said it's not a direct agonist. Instead of directly causing dopamine release, it acts as an allosteric modulator on DAT to affect reuptake.
I had a study in mind that found switching to MPH was effective at lowering the equivalent dose (the tolerance did not carry over), but my Googling is failing me right now. Appreciate the correction.
iroddis|1 year ago