[slicerdicer2]

GLP-1s have high quality double blinded placebo controlled RCTs proving them.

Does anything else you mentioned?

[dhfbshfbu4u3]

Couple do, though long term studies on a few are missing.

RCT-Proven: GLP-1 Agonists, mTOR Modulation (Rapamycin), NMDA Modulators (Ketamine), Metformin.

Speculative/Limited Data: Senolytics, Hormones and Peptides, NAD+, Nootropics and Adaptogens.

Keep in mind that the absence of published RCTs does not mean an intervention is ineffective; it may just be proprietary knowledge. Plenty of rich, private labs out there doing that kind of work today.