[kenjin4096]

This is a good point. We already observed this in our LTO and PGO builds for the computed goto interpreter. On modern compilers, each LTO+PGO build has huge variance (1-2%) for the CPython interpreter. On macOS, we already saw a huge regression in performance because Xcode just decided to stop making LTO and PGO work properly on the interpreter. Presumably, the tail call interpreter would be immune to this.