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_ihaque | 11 months ago

No, it's not a reformulation of tirzepatide. Orforglipron is a small molecule with a molecular mass of 883 g/mol and tirzepatide is a large molecule peptide six tims larger, with a molecular mass of 4813 g/mol.

The Wikipedia pages are decent -- the picture makes it fairly obvious how much smaller orforglipron is than tirzepatide even if you don't know how to read chemical structures; just count atoms!

https://en.wikipedia.org/wiki/Orforglipron

https://en.wikipedia.org/wiki/Tirzepatide

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hollerith|11 months ago

Also, tirzepatide is a peptide whereas orforglipron is not.

loeg|11 months ago

GP mentioned that.

> tirzepatide is a large molecule peptide