[grw_]

I don't think Threadripper platform is to blame that you bought a board with potentially the worst possible pcie lane routing. Latest generation has 88 usable lanes at minimum, most boards have 4x 16x, and Pro supports 7x Gen 5.0 x16 links, an absolutely insane amount of IO. "At the mercy of motherboard design"- do the absolute minimum amount of research and pick any other board?