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forgotpwagain | 10 months ago

Indeed, now is the moment to step on the gas in biotech. The past 15 years have been nothing short of extraordinary in the field. We finally have the tools needed to effectively measure biology, manipulate biology, and increasingly predict biology. More recently, we have been able to turn more and more problems into computational problems.

With all of this coming together, we should be accelerating both public and private investment in biotechnology because we're getting closer and closer to transformative therapies. But...we're failing to rise to the occasion and meet the moment.

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EMIRELADERO|10 months ago

Could you give some examples/directions for interesting things that have popped up in the period you're mentioning? Sounds like a fun time.

eig|10 months ago

The entire class of "biologics" drugs only came about in the past 15 years thanks to advances in sequencing and biotech. They are the mainstays of treatment for dozens of serious dermatologic, rheumatologic, and GI diseases, not to mention they directly cured multiple cancers.

DrAwdeOccarim|10 months ago

Not op, but I’m in the field and can give you some things to read about:

- CAR-T

- CRISPR

- PRIME editing

- Base editing

- Modified mRNA

- PD-1 inhibitors

- On the cusp of personalized cancer vaccines

- ADCs

- Structure correctors

- Targeted protein degraders

- siRNAs

These have all really hit their stride in the past 15 years. Guess where all of them initially came from? Random ass government-funded academic research. Sure, you can split hairs with me on the 15 years and NIH/NSF etc funding, but it’s basically true. We are killing the golden goose…

mac-mc|10 months ago

Tools wise cheap sequencing is a big one.

kwere|10 months ago

biotech, outside of curing most illnesses (except trisomy of 21 or others) is a very touchy field that most politicians would steer clear