[getpost]

> everyone should be aware that it’s very likely that each MDMA dose is incurring some level of damage

I think this is overstating the risk in supervised clinical usage, depending on what you mean by "some level of damage." It's possible that a single alcoholic beverage may induce some level of damage, but that is irrelevant for most drinkers. A more realistic comparison might be the risk associated with surgical anesthesia, which is significant, but that doesn't mean surgery should be necessarily avoided. There are always risk/benefit tradeoffs, and the MAPS research has focused primarily on MDMA use after other therapies have failed.

The MAPS Investigator's Brochure[0] acknowledges that, while preclinical studies in animals have shown serotonergic neurotoxicity at high or repeated doses, there is as yet no consistent evidence of neurotoxicity in controlled clinical settings with limited dosing. The report characterizes high-, medium-, and low-level risks. No high-level risks were identified, and medium-level risks are mainly cardiovascular and psychological.

[0] https://maps.org/wp-content/uploads/2023/04/MDMA-IB-15th-Edi...