[zharknado]

> This is somatic editing. These edits will not be inherited.

Genuine question- how do we know that? Is it just that the edits are very improbable to accumulate in the gonads in sufficient quantities to persist? We can’t actually prevent some fraction of them from reaching other parts of the body, right?

[burnt-resistor]

I'd like to know that too. When a gene therapy is administered to a person after birth, what % of cells get the edit and with what approach(es)? Doesn't that also edit oocytes and spermatocytes too?