[myth2018]

Glad to hear you are well. Also because that gives me some more hope.

> which seems to have some weird comorbidities

I'm a bit shocked by your list of comorbidities. Not only yours, but also the one you linked to. MCAS is currently among my most pressing concerns, although it seems to be getting under control with H1 and H2 antihistamines + cromoglycate. An anti inflammatory diet also helps, even though I'm struggling to stay completely away from sugar. The psychiatric part calls my attention. I also present some traits of ADHD and ASD, although not enough to complete a diagnosis. Twenty years ago I joined mensa at the 99th percentile, but I do believe my IQ has decreased significantly since then. I can't even remember the last time I had, in my adulthood, my mind as functional as I used to have in my teenagehood, even before covid and the aggravation of the symptoms.

Out of your list, the only item I couldn't relate with were the medications working less than expected. In my case, I usually have stronger effects, both therapeutic and side ones. That happens with vaccines too. However, last weekend I took one for Influenza and the side effects were barely noticeable for the first time in my adult life -- I hope that's a result of the MCAS treatment.

[cjbgkagh]

It's a long list right, most doctors will think you're just being a hypochondriac, that's what they told me and my family for decades. A general distrust of doctors might as well be another comorbidity.

It certainly sounds like a TNXB subtype of hEDS, this is an unofficial subtype, I read about the theory here on HN many years ago and ran with it. With an IQ that high I would take a guess that you have 2 TNXB SNPs. I'm happy to share more details on what has been figured out about these specific genes, I'll add an email address to my account.

I don't think the IQ points have been lost forever, I think I've recovered to my peak and possibly surpassed it with carful management of the meds. I think the general case of child prodigies burning out is simply a case of them not being able to get effective treatment and not an unavoidable innate quality.

Sugar is is still a tough one for me, it tends to give me headaches rather quickly which does make it easier to avoid it, but the desire for candy is always there.