[unignorant]

I do a lot of ML work too and recently gave NixOS a try. It's actually not too hard to just use conda/miniconda/micromamba to manage python environments as you would on any other linux system with just a few lines of configuration. Pretty much just add micromamba to your configuration.nix plus a few lines of config for nix-ld. Many other python/ML projects are setup to use docker, and that's another easy option.

I don't have the time or desire to switch all my python/ML work to more conventional Nix, and haven't really had any issues so far.