Selegiline is also known as Emsam, the patches reportedly Sam Bankman-Fried was on, alongside ADHD meds. I recall reading how this may have been a large driver of his compulsive risk it all decision making that eventually brought it all down.
Delivery through transdermal patch (Emsam) is different than other presentations of Selegiline, and we don't know the doses he was on. I've heard a low dose of Emsam (6mg) gives a better, more stable dopamine baseline, without getting into MAO-A inhibition that happens at upper doses.
> I've heard a low dose of Emsam (6mg) gives a better, more stable dopamine baseline, without getting into MAO-A inhibition that happens at upper doses.
This is the broscience theory that you find on Internet forums, but it didn’t play out positively in the actual clinical trials. Getting into full MAOI inhibition was necessary for positive effects.
The “more dopamine” theory appeals to people who treat the brain as a simple machine where you’re adjusting levels of different chemicals, but doesn’t really work out in practice. Dopamine is the neurotransmitter du jour in these circles, but mood and mental health are more than one chemical.
mickelsen|8 months ago
Aurornis|8 months ago
This is the broscience theory that you find on Internet forums, but it didn’t play out positively in the actual clinical trials. Getting into full MAOI inhibition was necessary for positive effects.
The “more dopamine” theory appeals to people who treat the brain as a simple machine where you’re adjusting levels of different chemicals, but doesn’t really work out in practice. Dopamine is the neurotransmitter du jour in these circles, but mood and mental health are more than one chemical.