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I have a fairly unusual genetic disorder, and quite rare to boot in this particular variant. The gold standard cocktail contains a medication which, while effective in dealing with one facet of the pain, absolutely turns down the dimmer switch on my mind in fairly particular ways. Gait is affected the next day, along with a mild aphasia. During the peak, however, I am dumb as a box of rocks. Math and spatial business seem fine. I can still program, however. Just do not talk to me, as communication is ... troublesome.

I usually skip this portion of the cocktail unless things are particularly bad. The disorder is progressive, so when it comes for my brain, well, that's when things are over. I do not have much going on for me in terms of personal value except for, well, solving problems.

A very close friend of mine has had two hospitalizations for gangrene, and the second one absolutely devastated his cognitive abilities. He has leveled off at about eighty-five percent of where he was before. If he is tired or feeling unwell, verbal perseveration begins.

My mother is fairly well-on in her years. She used to have a tremendous vocabulary, despite her very limited education. Now, she has begun to lose words and I end up "translating" for her because I know what she is getting at. She could do crosswords but refuses to, even the Monday selections, which are typically the easiest. Very recently, she has begun misplacing things. I had my suspicions, and during a routine head, neck, and brain imaging for something else, I checked out the results and, sure enough, some loss of volume in the right hippocampus.