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ocrow | 8 months ago

The drawback of Ibuprofen is that it tends to cause damage to stomach and intestinal linings. That's why you are advised to take with food and/or lots of water. You don't want it absorbing all in one place. Long term use exacerbates the effect, making it more likely to cause ulcers and eventually internal bleeding. My partner ended up in the hospital with a serious internal bleed caused by taking Ibuprofen daily for chronic pain. I'm not saying don't use it, just be aware of the risks.

https://pubmed.ncbi.nlm.nih.gov/9715832/

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lq9AJ8yrfs|8 months ago

Ibuprofen is possibly worse than that, it seems that it may interfere with sex hormones. [1]

This 2017 study I found in 30s of searching is seemingly underpowered at n=30 or so, but the (preliminary) implication is awful enough that I won't give my boys ibuprofen at all. Out of abundance of caution.

They can have naproxen or acetaminophen instead -- we keep those out of reach and teach our children not to touch them without adults.

Perhaps there is some more recent research?

[1] https://www.pnas.org/doi/abs/10.1073/pnas.1715035115

colaco|8 months ago

And also kidney failure in prolonged use, usually in patients with any sort of previous kidney damage.