[jjallen]

Everything is at least partially genetic.

We have a friend whose sister has it and she went to genetics counselors before having kids.

They told her that because her sister has it that her kids had a 20% likelihood of developing it. Obviously 20% is way higher than normal.

[SoftTalker]

Be sure you understand what this means. 20% higher chance (of a 1% baseline) is vastly different from a 20% chance.

[jajko]

I think its pretty clear which case is being discussed. 20% increase in chance is not something to generally worry about.

[jjallen]

This is through the grapevine. I thought they said 20% likelihood, not 20% higher likelihood. But this isn’t me and I don’t know the numbers well.

I do know that this woman chose to not use her own eggs for their child. And you would think that going from 1-1.2% would not make you do that. Perhaps there is another variable involved that I am unaware of. Her sister developed it after their parents divorce in her 30s fwiw.

[lazyasciiart]

That is much, much higher than I am aware of - and my mother's sister has schizophrenia so I did look this up a while ago. And the outcome so far is 0 cases in 25 nieces and nephews, all of us in our mid twenties or older.