Vitamin C Boosts Epidermal Growth via DNA Demethylation

[ggm]

In cell cultures. So nothing about topical, or digestive pathways. Just, expose cells to vitamin c rich medium.

How would topical application work, and what kind of homeostasis effect, from ingestion.

If you are low on vitamin c in your diet, sure. If not, you may not get much benefit from having more.

[ethan_smith]

Topical vitamin C (L-ascorbic acid) at concentrations of 10-20% with pH <3.5 can penetrate the stratum corneum, though stability and formulation significantly impact bioavailability.

[majkinetor]

Everybody is low on C in diet. It's thermolabile, and there is glucose competition for GLUT transporters.

IMO, everybody should take at least 2g daily in a couple of doses, particularly smokers.

[cookiengineer]

Maybe plasters with ascorbin acid in it? That would be the first thing that comes to mind. Or maybe plaster spray where it's mixed with the typical protein foam?

[burnt-resistor]

Oh lord, not another "wellness hack". And here comes the people giving themselves kidney stones and spinal cord problems to be featured on Chubbyemu.

https://youtu.be/oeyt2zVqCG8

[cultofmetatron]

honestly that video was surprising on how safe zinc is. I mean he went so beyond anything close to a reasonable dose. bro was eating tubes of dental paste.

[farseer]

Vitamin C supplements and cancer risk is an active area of research. Unless there is a genuine deficiency, I would stay away from supplements just to look pretty until there is more clarity.

[richarlidad]

Vitamin C’s relationship with cancer risk appears complex and context-dependent. While maintaining adequate blood levels (≥60.19 μmol/L) is associated with reduced cancer mortality, supplementation may increase postmenopausal breast cancer risk by 32% in women with already high dietary intake. This suggests a U-shaped relationship where both deficiency and excess may be detrimental, emphasizing the importance of personalized approaches to vitamin C intake.

See: https://inspectsupplement.com/vitamin-c/#Cancer

[metalman]

Vitamin C/ascorbic acid/swimming pool cleener is interesting stuff, but it is not generaly benificient as a suppliment for healthy people. I will(very) occasionaly chew up a gram, or throw a spoon full into a summer drink concoction, but I also know someone who got a tounge blister from copying me chewing up a vitC pill, someone I knew well, who had such different respinses to things that we started to experiment lightly,they also had a variant form of collegen in all of there conective tissue, which made them vastly more flexible than most people......which(oddly)relates to the titles subject matter

[woleium]

So possible treatment for age related thinning of the skin.

[kanbankaren]

Well, there are already multiple skin creams with Vitamin C. They have been available for a long time, but they are expensive for what it provides.

Just taking a 500mg x 2 Vitamin C supplements should provide enough for skin repair.

[MangoToupe]

Therapy is another option

[apt-apt-apt-apt]

So true. I have been vitamin-C deficient the past 20 years and my skin has definitely degraded.

[BugsJustFindMe]

> the past 20 years

That's called aging.

[SlowTao]

As a vaguely related aside, my skin is typically better when I have a decent vitamin c intake. Essentially all I do is have a orange or two every night. Nothing too extreme.

This is VERY anecdotal!

[jandrewrogers]

Oranges are not particularly high in ascorbic acid as such things go, so I would expect any effect to be pretty marginal. Other fruits and vegetables contain considerably more.

[radu_floricica]

This just found a potential mechanism, right? Because we did know that, AFAIK. A doctor recommended me vitamin C for faster healing of minor lesions about a decade ago.

[sydbarrett74]

With conflicting evidence that vitamin C may promote tumour growth, how much study has been done as to whether this might exacerbate skin cancer?

[inkyoto]

… coffee is good for you, coffee is bad for you. Table salt is bad for you, table salt is good for you. Red wine is good for you, red wine is bad for you. We have gone a full circle on each of those so many times.

Linus Pauling used IV injections of vitamin C in 1970's to treat terminal cancer tumours, subsequent studies in 1990's failed to reproduce the effect so it was abandoned (and discredited), and over the past decade the interest has rekindled the research and phase 3 trial is underway for high dose IV injections of vitamin C as adjuvant therapy for pancreatic and solid cancer tumours[0].

[0] https://link.springer.com/article/10.1007/s12094-024-03553-x

[deadbabe]

This is why you need to include a good vitamin C serum in your daily skincare routine.

[m463]

"I always use an after-shave lotion with little or no alcohol because alcohol dries your face out and makes you look older. Then moisturizer, then an anti-aging eye balm, followed by a final moisturizing "protective" lotion..."

Bateman stares into the mirror. The masque has dried, giving his face a strange distorted look as if it has been wrapped in plastic. He begins slowly peeling the gel masque off his face.

[mmmpetrichor]

I get all my skincare advice from hackernews.

[oneshtein]

Which daily skincare you recommend to use?

[WhereIsTheTruth]

or invest in a steam cooker and stop eating junk food?

[JumpCrisscross]

A, B, C, D, E and water.

A is a light retinol. B is niacinamide. C is C. D you should be making from sunlight (or getting from supplements). E is E. Water is moisturiser.

Pretty much all evidence-based skincare comes down to providing these vitamins (plus water) to your skin.

[brador]

Could be why so many suggested home skin remedy moisturisers contain lemon juice.

[epcoa]

Pauling spins furiously in his grave in approval.