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HFCS is a sugar. The difference between HFCS and standard cane sugar is relatively minor - a 5% difference in the ratio of fructose to glucose.

There's some evidence HFCS is worse than sucrose (standard refined cane sugar) and some metabolic mechanisms to make that plausible, but it's a relatively minor difference compared to just the overall amount of consumption.

10 grams of "sugar" (sucrose) is 5 grams of fructose. 10 grams of high fructose corn syrup is 5.5 grams of fructose.

A diet going from 10 grams of any sugar per day to 50 or 100 grams of any sugar per day is going to have a drastically larger impact on health than if the 10 grams were sucrose vs HFCS.