[abruzzi]

Mounjaro uses a single use fully autometed injector--clean your skin, remove the cap, press the injector against your skin, then press a button. A springloaded needle penetrates you skin and a spring loaded plunger injects the medicine. You have no way to pull backthe plunger to see if you are in a vein/artery.

I've never used Ozempic, but my understanding was it used a device similar to insulin pens--dial you dosage, attach needle, insert needle, press at the base of the pen to inject the selected amount. Also no way to pull back to see if you hit a vein/artery.

[wormius]

Yeah, both Ozempic and Trulicity have automated systems like this, just press a button and pop. Is there even a way to hit a vein? The needle is not very deep (it's subcutaneous, just barely under the skin). And it's the stomach, which AFAIK, doesn't have a lot of exposed veins?

Either way super simple and quick. Fairly painless. I had a weird rash one time, but apart from that a total of about 15 injections haven't had any issues on either Ozempic or Trulicity in terms of injections. Others may have difficulties, but it's been super easy IMO.

[sroussey]

You can get these drugs with a vial and needles and it’s cheaper that way. Not familiar with the autoinjectors, but the instructions when using a vial and insulin needles is definitely to pull back.

Peptides don’t have the same negatives as say insulin, but preferable to not have them in your bloodstream nonetheless.

[dmurray]

> And it's the stomach, which AFAIK, doesn't have a lot of exposed veins

And it's mostly for people who have plenty of stomach fat, so even less chance of hitting something else.

[asmor]

Mounjaro uses very different designs across the world. The UK has an included needle; here in Germany you need to get them yourself, and neither is an auto-injector.

[randallsquared]

This is right. It's all or nothing, and there's no "pull back" functionality.

[sroussey]

Only on the autoinjectors. Not true with the vial and insulin needles.