[leereeves]

That's right, they use N1-Methylpseudouridine instead of uridine (the nucleoside contained in uracil, which is the U in mRNA sequences) to last a bit longer (but not forever) and to avoid triggering immune reactions to the mRNA itself (the immune system can detect foreign mRNA).

Certainly the vaccine's mRNA sequence breaks down into separate nucleotides. If it did not, continued production of the antigens would cause a chronic immune reaction and/or immune exhaustion that would make the vaccine ineffective.

I don't know what happens to the N1-Methylpseudouridine though. That's an interesting question.

[msandford]

> Certainly the vaccine's mRNA sequence breaks down into separate nucleotides. If it did not, continued production of the antigens would cause a chronic immune reaction and/or immune exhaustion that would make the vaccine ineffective.

I suspect you just described "long COVID" or "vaccine injury" for some fraction of folks.

[amy_petrik]

Also, people are usually like LOL it's just mRNA it goes away

But evidence does show it CAN go back to DNA with mechanisms familiar to anyone edgycated in molecular genetics - https://pubmed.ncbi.nlm.nih.gov/35723296/

Now, that particular study is in whatever cell line, highly dubious how it pertains to a human body, a few steps removed. But if you say "will you see this if you vaccinate 500 million times in 500 million people each with 500 trillion cells" - yea probably you would