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forgotpwagain | 7 months ago
There is also one widespread approach that isn't mentioned in the article: expansion microscopy. Expansion takes the scifi-sounding approach of: what if you could make your sample physically bigger? See the Wikipedia page for more: https://en.wikipedia.org/wiki/Expansion_microscopy
ClaraForm|7 months ago
1. Stephen Hell has been theorizing about how to do super-res microscopy since the mid-90s, so the article saying it was sci-fi "20 years ago" is off by about 10 years.
2. Stephen Hell has recently given the world another new technique, MINFLUX, which seems to be his best gift to super-res researchers so far. :)