[carom]

Ok, hold up. This study came up on Reddit a few weeks ago and my wife linked it to me. A lot of the comments were similar about how vaccine skeptics will never be convinced by it. So, being a vaccine skeptic, I went and read it.

>In this primary analysis, except for Asperger syndrome (hazard ratio, 1.13 [CI, 0.89 to 1.44]) and atypical autism (hazard ratio, 0.94 [CI, 0.79 to 1.12]), estimates for the individual outcomes were incompatible with any increased risk, with the upper bounds of the 95% CIs below 1.00. [1]

My understanding of this, and I am a software engineer so take it with a grain of salt, is that this study failed to disprove a link between aluminum in vaccines and aspergers! There is another section where it appears they played with the hyperparameters of their study and ended up with a lower hazard ratio for aspergers (I believe by extending the analysis window to 8 years of age, but it wasn't clear to me).

>Except for Asperger syndrome (hazard ratio, 1.02 [CI, 0.93 to 1.12]) and atypical autism (hazard ratio, 0.95 [CI, 0.88 to 1.03]), estimates for the individual neurodevelopmental outcomes assessed were incompatible with any increases in risk, with the upper bounds of the 95% CIs equal to or below 1.00.

That is to say, after reading the study, I am not convinced at all. I would like to see a longer analysis period (e.g. to 50 years of age) as many things go undiagnosed until later in life. From my reading though, this study failed to disprove a link despite what all the popsci headlines are saying.

1. https://www.acpjournals.org/doi/10.7326/ANNALS-25-00997

Edit: I know I am going to catch downvotes for this, but please go read the study and let me know where I am incorrect!

[loveiswork]

The fact that the confidence interval range includes 1 means that the finding was not statistically significant.

The population for those two specific diagnoses were low in the study. Diagnostic patterns change over time for these type of disorders. Considering neurodevelopmental outcomes as a group may add more color.

You are correct that the study failed to disprove a link between aluminum and aspergers. But the study did prove a that if there is a link it does not result in a moderate to large increase in aspergers risk.

[SubiculumCode]

It's called uncertainty. Do you see the confidence intervals on the log hazard ratios? They did not significantly differ from 1. In part this is because Asbergers and atypical autism were underpowered compared to the main autism group. Also note many were below 1, meaning LESS chance of getting that diagnosis.

[aradox66]

I'm also not an expert here, but looking through the figures [1], that one HR result for Asperger's in a figure 4 is...surprising to see, given the headlines.

This is far from strong evidence of an effect, but you're absolutely right that this at least deserves discussion in the paper and coverage.

1. https://www.acpjournals.org/doi/suppl/10.7326/ANNALS-25-0099...

[kikki]

What exactly is a vaccine skeptic - in your opinion? What are you skeptical of?

[carom]

The other comment articulates the points much better than I would have, but I have a large number of (tested) food and environmental allergies. It is a very logical explanation that the adjuvants in vaccines would cause the body to also train an immune response to other things.

There is also a massive profit motive for pharma companies and many hospitals, when you couple that with the revolving door between industry and government, it seems like a situation ripe for corruption.

I don't see the harm in removing aluminum adjuvants from vaccines (we all buy aluminum free deodorant!). I don't see the harm in not vaccinating children for things they are unlikely to come into contact with (i.e. hepatitis B). In fact, I think it would be good to make the change and see what the health outcomes are over the next 30 years. That is how we will learn.

[plqbfbv]

I would guess people that don't know how stuff works or what they're talking about, but still feel entitled to disregard medical science progress because they don't see the effects directly.

Seeing my father in law daily is a very good reminder to me as to why we thought eradicating polio (and creating vaccines) was a good idea: his left leg is 30% the size of his right leg, and he's had trouble walking since he was 7yo (he's now 65), with no way of fixing it.

People don't understand what life used to be like before 60y ago because they didn't live through it, and even then they're tempted to dismiss the death or permanent complication rates because "nobody died"... that they knew/recall of.

It's true that in general better sanitation, clean water, better food availability have helped in reducing the death rates in general and also complications (because better prepared immune system, better symptoms management, ...), but vaccines allowed to eradicate stuff that killed or altered lives permanently on a regular basis.

[mousethatroared]

- Adjuvants. As a materials researcher I think it's nuts we inject nanoscale alumina in our blood.

- Regulatory structure. Why can't I sue a vaccine manufacturer? Limit awards, if you necessary, but if I cant sue I cant get discovery.

- Effectiveness. The flu vaccine's effectiveness is statistical artifact. See healthy vaccine bias

- Historical effectiveness. I had a civil engineer smugly point out that his profession had ended more diseases than biology. So I looked it up. Civil engineering did more to end communicable diseases than vaccines.

- General dishonesty of the medical profession. I don't expect my Advil to be 100% safe; I don't expect my vaccine to be either. I dont expect my medical health officers to lie about it though (see mRNA and the long dismissed myocarditis risk)

[sndean]

This is more of an issue with there being a low number of cases (both < 300) for of those two Neurodevelopmental Outcomes categories than anything else.

[kmonad]

read up on what confidence intervals are.