[neallindsay]

I don't think that blueflow is being obtuse at all. If you assert that genes have an intended way of working, then the questions

> How do we know how things are intended to work? (Intended by whom?)

are very salient. Your reply talking about

> …a specific receptor in the body is not working properly.

just raises the same question again. What does it mean for something in our biology to be working "properly"? Who is deciding what is "proper"?