[ljchen]

I most agree, only except that perf is determined by a myriad of facors. Even if this piece of data fits into a cache line, it may have no or negative effect on the following code. For complex softwares, even if it's faster after the change, it's hard to tell what's the contributing factor really is. I once read a system paper (forgot the name) from a recent system research conference on how changing the code layout, e.g., moving a block of code, randomly may have unexpected impacts on perf.

Personally, I only pay attention to the cache line and layout when the structure is a concurrent data structure and needs to sync across multiple cores.