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Nesco | 6 months ago

I am pretty sure uncouplers will make a come back. Just something a little more targeted and safer than good ol’ DNP

discuss

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loeg|6 months ago

But why? Ozempic et al solve the input end of the equation. Burning more and literally being warmer isn't better.

cthalupa|6 months ago

I would agree, personally - I won't go near DNP, and even the newer stuff like BAM15 that is supposed to be incredibly selective I am quite suspicious of.

But you still see people losing tons of weight on GLP-1s wanting it to go faster, drop more pounds, etc.

I'm a big proponent of them - and I have enough risk tolerance that I'm on grey market retatrutide - but I see a lot of people that want to just keep adding more and more chemicals to the equation to solve the issue. I've taken the time to significantly modify my food and exercise habits, and believe that I'll be able to maintain my weight loss if I were to go off of the GLP-1. But a lot of people haven't. They eat the same bad food, just in lower quantities, don't increase their protein and fiber intake, don't exercise, and just up the dose or add a new compound when their rate of weight loss doesn't satisfy them.

There's tons of interest in BAM15, clenbuterol, and all sorts of experimental substances. Tons of people taking things like tesamorelin and ipamorelin too.

I think the GLP-1s are basically miracle drugs that have allowed a lot of people, including myself, to totally revamp their approaches to diet and fitness. But there's a lot of people that are going to be more than happy to increase their cocktail with anything they think will get them skinny faster.

nkmnz|6 months ago

looking for this, hu? https://en.wikipedia.org/wiki/HU6

Nesco|6 months ago

Yes, but also BAM15 and mRNA based UCPs overexpression

Longer term if it works more research in the domain, including variations of the other well known ones (DNP, XCT-790, mitoCCCP, …)

I firmly believe that combined with:

- additional progress on the current targets (GLP-1, GIP, …)

- compounds to counteracts muscle loss like myostatin inhibitors

- food options being shaped by more health conscious consumers

Having a slow metabolism will stop being an disadvantage by midcentury