The only effect of applying to jobs on jobs.now is that someone who is already working in the US on H1-B, and was gonna get green card if you hadn't applied, would instead stay on H1-B.
Another thing is that the company must respond to your application within 30 days. Unlike Indeed or Linkedin applications which simply disappear into a void.
H1-B visas eventually expire. I think it’s technically a guest worker visa, so the expectation is that the visa holder will go back to their home country after working in the US a few years.
H1-B is an immigrant intent (actually dual intent) visa. I know a lot of Canadians that started working in the US on a TN visa, which doesn't let you ever become a permanent resident. They had to do all the paperwork (and win the lottery) to convert to H1-B status so they could begin the process of getting permanent residency.
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