[adamgordonbell]

Also this:

> The best reason to take multiple life extension supplements is to hedge our bets, because we really don’t know which of them are effective in humans.

And earlier:

> Personally, I take large doses of rapamycin 2 days a week, 8 weeks per year. For personalized recommendations, you can consult your favorite life extension doc.

[obloid]

I recently saw a patient with overwhelming MRSA sepsis with multiple foci of infection including epidural abscess (around the spinal cord), and meningitis. This person was taking rapamycin presumably for "life extension" purposes. Almost certainly the immunosuppression from the rapamycin made the infection much worse.

I'd be very wary of taking an immunosuppressive drug as an otherwise healthy person for theoretical life extension properties.

[rscho]

Don't come and spoil our nice individualism with populational effects, you filthy rationalist !

[OutOfHere]

What was the dose and frequency? I bet it was rather high. Or do you really think that 1 mg once per week will suppress the immune system?

[cactusplant7374]

Rapamycin modulates the immune system. I get that he's probably consulting a doctor but can you imagine taking this risk during a pandemic or even in older age? It makes me uncomfortable to play around with these very powerful drugs.

[YZF]

The dosage for longevity is supposed to be low enough that this risk is minimized. Lots of things you do modulate your immune system (including e.g. exercise). It's a risk/reward thing, every time you get into your car you're also taking a longevity risk.

I think there are some proper human trials happening but the jury is still out.

[jordanb]

These roads people go down always arrive at eating collidal silver...

[rscho]

How to hedge a bet 101:

1.you bet on risky stuff using something of value (money, health,...)

2.since you're unsure whether your bet will pay off, you bet some more on some other risky stuff, just to be sure.

BTW if you were wondering, of course all those proposed weird life-prolonging treatments are totally devoid of side-effects.

[BobaFloutist]

Never put 100% of your savings into a single slot machine. Take 10% of your savings to 10 different casinos and distribute them to 10 slot machines in each, in order to hedge.

[malfist]

Oh there's plenty of people selling "side effect free" life extension supplements. But there's another name for side effect free medication: effect free.