[IceHegel]

There's a fascinating tension with anti-aging drugs, which is that your preference would obviously be to take them as early as possible, so you spend more time at a younger age as opposed to just prolonging the last years of your life, where you'll be stuck in a nursing home anyway.

But taking experimental drugs while you're young is also much higher risk, and you might see people sacrificing their 20s for the sake of their 70s in a way they end up regretting, even if there aren't any side effects.

[chasil]

Taurine and Vitamin E are readily available and seem prudent.

For melatonin, tryptophan plus niacin would maximize the serotonin pathway (note this is dangerous when used with SSRIs).

How many of these are easily available? I had no idea that royal jelly is sold as a supplement.

[impure-aqua]

Of the prescription options, estradiol is probably the most common and easily available, between hormonal birth control and HRT.

It is also likely the most easy to study, as we have 60-70 years of usage that is not correlated with prevalence of other diseases that might skew life expectancy (like metformin etc.), and quite high-quality medical records by virtue of it being vended on a prescription basis.

Despite this, there is not really any clear evidence that it increases life expectancy.

[IAmBroom]

> I had no idea that royal jelly is sold as a supplement.

Given that actual honey on the shelf is often mere sugar water, and people buy chakra-alignment crystals online, what about the idea surprises you?

[gddgb]

Don’t listen to this stuff, he sounds so confident but it’s like he’s stapled together info nuggets. This isn’t like a thing people know with certainty.

[florbnit]

There's also a fascinating tension with physical exercise, which is that your preference would obviously be do it as early as possible, so you spend more time at a younger age as opposed to just prolonging the last years of your life, where you'll be stuck in a nursing home anyway.

But doing exercise while you're young is also much higher risk, and you might see people sacrificing their 20s for the sake of their 70s in a way they end up regretting, even if there aren't any injuries.

That said, even with risk of injuries it feels like a no brainer to be active and to be active from an early age.

Also I don’t think people should wait until their late 50ies to make sure they get enough vitamin c to “avoid sacrificing their 20ies”

[lumost]

If we really manage to crack the code on aging, How certain are we that it's merely something to be delayed? Apparent age is at least somewhat reversible via lifestyle factors e.g. diet/exercise/sobriety.

[DennisP]

In fact that's Aubrey de Grey's approach: rather than trying to figure out all the complicated processes involved in causing the damage in the first place, so you can slow them down, just directly fix the damage afterwards. There's been quite a bit of research on this.

[jijijijij]

I presume, death by accident becomes a statistical certainty rather quickly.

[jaggederest]

Especially selegiline, MAOIs are dicey business.