For me, the real 'click' moment with core.async wasn't just about replacing callbacks. It was realizing I could model entire business processes as a system of communicating channels. It completely changed how I think about system design.
Rich Hickey actually did a talk called "Language of the System" https://www.youtube.com/watch?v=ROor6_NGIWU way back in 2013 before core.async was even created that lays out a lot of the ideas. It even has a big section explicitly about "flow" which contains the germs of core.async.flow.
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